Genomic instability in induced stem cells
نویسندگان
چکیده
منابع مشابه
Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells
The generation of induced pluripotent stem cells (iPSC) from adult somatic cells is one of the most remarkable discoveries in recent decades. However, several works have reported evidence of genomic instability in iPSC, raising concerns on their biomedical use. The reasons behind the genomic instability observed in iPSC remain mostly unknown. Here we show that, similar to the phenomenon of onco...
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The discovery of induced pluripotent stem cells(iPSCs) is a promising advancement in the field of regenerative medicine. Previous studies have indicated that the teratoma-forming propensity of iPSCs is variable; however, the relationship between tumorigenic potential and genomic instability in human iPSCs (HiPSCs) remains to be fully elucidated. Here, we evaluated the malignant potential of HiP...
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Cancer is caused by successive gene mutations that amount to confer malignant phenotype. Genomic instability is considered a key endogenous mechanism for accumulation of mutations, and therefore, has been proposed as an engine of tumorigenesis. Recently, cancer stem cells, or tumor initiating cells, have been identified in a variety of human cancers. These cancer stem cells are believed to be r...
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Objective: Understanding how genomic instability could be involved in the regulation and establishment of cell lineage commitment during embryonic stem cell differentiation would provide crucial knowledge of stem cell biology. The aim of this study was to determine novel molecular biomarkers located near embryonic developmental genes responsible for embryonic stem cell signals that govern in vi...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2011
ISSN: 1350-9047,1476-5403
DOI: 10.1038/cdd.2011.9